News

The Final ImResFun Scientific Conference of the EC-funded Marie-Curie Initial Training Network ImResFun is now announced.

Publication: Candidalysin is a fungal peptide toxin critical for mucosal infection

ITN Practical Course "C2a", Barcelona, Spain (May 10-15, 2015)

ITN Meeting, La Colle sur Loup, France (May 16, 2015)

HPF2015, La Colle sur Loup, France (May 16-22, 2015)

ITN Practical Course "S3" & "C3", Madrid, Spain (July 6-10, 2015)

ITN Mid-Term Review Meeting, Vienna, Austria (November 3, 2015)

ITN Practical Course "S5" & "C5", Tübingen, Germany (May 9-11, 2016)

ITN Lecture Course "S4" & "C4", Szeged, Hungary (July 2-8, 2016)

ITN Practical Course "S6" & "C6", Göttingen, Germany (October 26-28, 2016)

ITN Symposium "S7" & Final Consortium Meeting, Innsbruck, Austria (January 28-30, 2017)

 

Name & Address

Uwe Gross Portrait

Prof. Dr med Uwe GroßWP2 Leader
Institute for Medical Microbiology, University Medical Center Göttingen
Kreuzbergring 57, D-37075 Göttingen, Germany
Phone: +49-551-39/5806 FAX: +49-551-39/5861
e-mail:
Web: www.bakteriologie.uni-goettingen.de & www.nrz-mykosen.de

ESR-UMG-GOE Project: (Start January/February 2014)

Fungal adaptations to the ageing host

By analysing clinical specimen from patients of different age groups, we seek to identify biomarkers that will help to discriminate between fungal colonization and infection and reveal potential adaptations to the ageing host. A specific focus will be laid on long-term regulatory events that modulate gene transcription levels on chromosomal telomers. In C. glabrata, for example, the telomeric regions harbour a large number of potential adhesin genes, whose alternative expression may facilitate immune evasion and differential adhesion to epithelial and plastic surfaces. Among other methods, we will attempt to detect biomarkers using mass spectrometric approaches. Eventually, this will serve to enhance diagnostic approaches currently under development within the consortium.

Main Research Interests

The Institute for Medical Microbiology is part of the infrastructure for one of Germany’s most renowned university hospitals. Non-fungal research is focussed on toxoplasmosis and bacterial pathogenesis. The institute is equipped with modern facilities for proteomics-, genetics- and cell biology-oriented research and a lively students’ community.

Today, numbers of fungal infections by Candida and Aspergillus species are on the rise due to more extensive use of immunosuppressants in various clinical settings. However, in many cases they are diagnosed to late or remain fully undiagnosed. The research at our institute has therefore focused on therapeutic and diagnostic procedures, including vaccination strategies for Aspergilli, fungal species identification (MALDI-TOF MS), and detection and understanding of drug resistance in various fungal species, including their epidemiology in Germany. Currently, we host the German National Reference Center for Systemic Mycoses, allowing access to a broad range of fascinating cases of fungal infections and diverse mycologic specimen.

At the interface of the groups of Dr. O. Bader and PD Dr. M. Weig, where this project will be conducted, different cell wall components are under evaluation as novel diagnostic targets. MALDI-TOF MS has been established as a usefull tool for species identification. Currently we are evaluating this technology for further applications such as biomarker identification, subtyping and resistance detection. Since in many cases cultural approaches fail to detect fungal pathogens, serologic profiling of patient blood is an urgently needed, but still underdeveloped field. We employ modern technologies such as Luminex to detect fungal antigens or serologic responses to species-specific cell wall components to exactly determine fungal pathogens present. Here, the discrimination of fungal colonization and fungal disease are most challenging.

Selected Recent Publications

O Bader, M Weig, U Reichard, R Lugert, M Kuhns, M Christner, J Held, S Peter, U Schumacher, D Buchheidt, K Tintelnot, U Groß; MykoLabNet-D partners (2013). cyp51A-based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany. Antimicrob Agents Chemother [In press].
PW de Groot, O Bader, AD de Boer, M Weig, N Chauhan (2013) Adhesins in human fungal pathogens: glue with plenty of stick. Eukaryot Cell 12(4):470-81.
O Bader (2013). MALDI-TOF-MS-based species identification and typing approaches in medical mycology. Proteomics 13(5):788-99.
O Bader, A Schwarz, EA Kraneveld, M Tangwattanachuleeporn, P Schmidt, MD Jacobsen, U Groß, PWJ de Groot, and M Weig (2012). Gross karyotypic and phenotypic alterations among different progenies of the Candida glabrata CBS138/ATCC2001 reference strain. PLoS One 7(12):e52218.
O Bader, M Weig, L Taverne-Ghadwal, R Lugert, U Groß, and M Kuhns (2011). Improved clinical laboratory identification of human pathogenic yeasts by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Microbiol Infect 17:1359-65.