News

The Final ImResFun Scientific Conference of the EC-funded Marie-Curie Initial Training Network ImResFun is now announced.

Publication: Candidalysin is a fungal peptide toxin critical for mucosal infection

ITN Practical Course "C2a", Barcelona, Spain (May 10-15, 2015)

ITN Meeting, La Colle sur Loup, France (May 16, 2015)

HPF2015, La Colle sur Loup, France (May 16-22, 2015)

ITN Practical Course "S3" & "C3", Madrid, Spain (July 6-10, 2015)

ITN Mid-Term Review Meeting, Vienna, Austria (November 3, 2015)

ITN Practical Course "S5" & "C5", Tübingen, Germany (May 9-11, 2016)

ITN Lecture Course "S4" & "C4", Szeged, Hungary (July 2-8, 2016)

ITN Practical Course "S6" & "C6", Göttingen, Germany (October 26-28, 2016)

ITN Symposium "S7" & Final Consortium Meeting, Innsbruck, Austria (January 28-30, 2017)

 

Name & Address

Toni Gabaldón Portrait

Toni GabaldónGroup LeaderImResFun Partner
Centre for Genomic Regulation (CRG), Bioinformatics and Genomics Programme
Dr. Aiguader, 88; 08005 - Barcelona, Spain
Phone: +34-933160281
e-mail:
Web: http://gabaldonlab.crg.es

ESR-CRG Project: (Start November/December 2013)

RNA-Seq to identify gene networks implicated in host-pathogen interactions

The ESR will use NGS strategies to elucidate the interplay between different species of pathogenic yeasts and the human immune system. He/She will develop and use a bioinformatics pipeline to gain biological knowledge from NGS data.

Main Research Interests

The main research interest of our group is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve across species. We generally use large-scale genomics, and phylogenetics approaches that allow looking at the evolution of genomes and transcriptomes, and we apply these analyses to a variety of biological questions. We have a special focus on the evolutionary mechanisms that have driven the emergence of fungal pathogenic species. Different Candida species may have evolved different virulence mechanisms to face the same human immune system, other mechanisms may be shared among different virulent species. We still lack sufficient understanding on what virulent mechanisms are playing a role in the different Candida species and how the have emerged and have been shaped during evolution. The problem of elucidating the mechanism for pathogenesis of Candida species, as proposed here, can be approached with an evolutionary genomics perspective by detecting specific adaptations in the transcriptional networks that are activated in the various species when faced to human macrophages.

Selected Recent Publications

Gabaldón T, Martin T, Marcet-Houben M, Durrens P, Bolotin-Fukuhara M, et. al. (2013). Comparative genomics of emerging pathogens in the Candida glabrata clade. BMC Genomics (in press

Gabaldón T, Koonin EV. (2013). Functional and evolutionary implications of gene orthology.  Nat Rev Genet.  14(5):360-6.

Capella-Gutiérrez S, Marcet-Houben M, Gabaldón T. (2012) Phylogenomics supports microsporidia as the earliest diverging clade of sequenced fungi. BMC Biol. 10:47.