News

The Final ImResFun Scientific Conference of the EC-funded Marie-Curie Initial Training Network ImResFun is now announced.

Publication: Candidalysin is a fungal peptide toxin critical for mucosal infection

ITN Practical Course "C2a", Barcelona, Spain (May 10-15, 2015)

ITN Meeting, La Colle sur Loup, France (May 16, 2015)

HPF2015, La Colle sur Loup, France (May 16-22, 2015)

ITN Practical Course "S3" & "C3", Madrid, Spain (July 6-10, 2015)

ITN Mid-Term Review Meeting, Vienna, Austria (November 3, 2015)

ITN Practical Course "S5" & "C5", Tübingen, Germany (May 9-11, 2016)

ITN Lecture Course "S4" & "C4", Szeged, Hungary (July 2-8, 2016)

ITN Practical Course "S6" & "C6", Göttingen, Germany (October 26-28, 2016)

ITN Symposium "S7" & Final Consortium Meeting, Innsbruck, Austria (January 28-30, 2017)

 

Name & Address

Renate Spohn Portrait EMC Logo

EMC microcollections GmbH
Renate Spohn
EMC microcollections GmbH
Sindelfinger Str. 3, 72070 Tübingen, Germany
Phone: +49-7071/4074-0 FAX: +49-7071/4074-22
e-mail:
Web: http://www.microcollections.de

ESR-EMC Project: (Start January 2014)

Chemical biology of anti-infective compounds and PRR-modulators

The ESR will apply modern chemical techniques in bio-organic and medicinal chemistry to synthesize, purify and characterize collections of small molecules with high potency of anti-infective activity. Organic chemistry on solid phase and in solution, purification methods and instrumental analytics will also be applied to develop new PRR agonists and antagonists involved in antifungal defense. In cooperation with the project partners, active compounds will be investigated for their growth inhibitory potential or ability to reduce tissue infections under adverse conditions.

Main Research Interests

EMC focuses on the generation and biochemical investigation of biologically and pharmacologically relevant organic compound collections and provides a full range of medicinal, combinatorial and computational chemistry services. Based on bioorganic chemistry, chemical biology and immunochemistry EMC holds a leading position in the areas of methods development and high throughput synthesis of validated compounds. Furthermore, the company provides a powerful spectrum of custom specific peptide- and peptidomimetic synthesis and biochemicals for basic research. Efforts are concentrated to improve the lead finding success rate by rational and random search strategies. EMC has leading knowledge in immunochemistry. Tools and methods include adjuvant evaluation, optimization and production, the development of therapeutic and prophylactic multi-component synthetic vaccines. EMC´s third generation vaccines are developed on the basis of synthetic lipopeptides. EMC is well equipped for peptide and peptide mimetic synthesis, synthetic ligand optimisation, efficient combinatorial organic and peptide chemistry, medicinal chemistry and chemical biology. Modern instrumentation for automated solid phase chemistry, purification and analytics, e.g. on-line HPLC/ESI-MS, are established.

Selected Recent Publications

Stiehm M., Peters K., Wiesmüller K.-H., Bufe A., Peters M. (2013) A novel synthetic lipopeptide is allergy-protective by the induction of LPS-tolerance. Clin Exp Allergy. 43(7):785-97.

Baleeiro R.B., Wiesmüller K.-H., Reiter Y., Baude B., Dähne L., Patzelt A., Lademann J., Barbuto J.A., Walden P. (2013) Topical Vaccination with Functionalized Particles Targeting Dendritic Cells. J. Invest. Dermatol. 20. doi: 10.1038/jid.2013.79.

Bauer, J., Kinast, S., Burger-Kentischer, A., Finkelmeier, D., Kleymann, G., Abu Rayyan, W., Schröppel, K., Singh, A., Jung, G., Wiesmüller, K.-H., Rupp, S. & Eickhoff H. (2011) High-throughput Screening-based Identification and Structure-activity Relationship-characterization Defined (S)-2-(1-Aminoisobutyl)-1-(3-chlorobenzyl) benzimidazole as a Highly Antimycotic Agent, Non-toxic to Cell Lines. J Med Chem. 13;54(19):6993-7.

Burger-Kentischer, A., Abele, I.S., Finkelmeier, D., Wiesmüller, K.H. and Rupp, S. (2010) A new cell-based innate immune receptor assay for the examination of receptor activity, ligand specificity, signalling pathways and the detection of pyrogens. Journal of Immunological Methods, 358(1-2):93-103.

Spohn R, Buwitt-Beckmann U, Brock R, Jung G, Ulmer AJ, Wiesmüller K-H. (2004) Synthetic lipopeptide adjuvants and TLR2 - structure-activity relationships. Vaccine 23, 2494-99.