News

The Final ImResFun Scientific Conference of the EC-funded Marie-Curie Initial Training Network ImResFun is now announced.

Publication: Candidalysin is a fungal peptide toxin critical for mucosal infection

ITN Practical Course "C2a", Barcelona, Spain (May 10-15, 2015)

ITN Meeting, La Colle sur Loup, France (May 16, 2015)

HPF2015, La Colle sur Loup, France (May 16-22, 2015)

ITN Practical Course "S3" & "C3", Madrid, Spain (July 6-10, 2015)

ITN Mid-Term Review Meeting, Vienna, Austria (November 3, 2015)

ITN Practical Course "S5" & "C5", Tübingen, Germany (May 9-11, 2016)

ITN Lecture Course "S4" & "C4", Szeged, Hungary (July 2-8, 2016)

ITN Practical Course "S6" & "C6", Göttingen, Germany (October 26-28, 2016)

ITN Symposium "S7" & Final Consortium Meeting, Innsbruck, Austria (January 28-30, 2017)

 

Name & Address

Hana Sychrová Portrait

Hana SychrováResearcherPartner 6 ImResFun
Institute of Physiology, Academy of Sciences of the Czech Republic
Department of MembraneTransport
Videnska 1083; 142 20 Prague 4, Czech Republic
Phone: +420-241062667 FAX: +420-241062488
e-mail:
Web: http://sun2.biomed.cas.cz/fgu/en/index.php?skript=oddeleni/316.php & http://www.biomed.cas.cz/~sychrova/index.php

ESR-FGU Project: (Start November/December 2013)

Regulation of intracellular ion homeostasis in Candida interacting with the host

The ESR will study the changes in cytosolic pH and cation concentrations upon interactions with host; will construct new mutant strains in order to identify and characterize transporters involved in proton and/or alkali-metal-cation homeostases as potential targets for development of respective assays supporting drug discovery. The project aims to characterize transport systems and mechanisms underlying the maintenance of membrane potential, intracellular cation and pH homeostases in Candida spp.

Main Research Interests

Our research interests focus on study of 1) cell transport systems and their mechanisms on molecular level with the employment of yeast to characterize transport systems in mammalian and plant cells; 2) molecular basis of the high osmotolerance in non-conventional yeasts – identification of genes responsible for extremely high osmotolerance, their functional expression in industrial S. cerevisiae strains; 3) development of tools for genetic engineering of non-conventional yeasts; and 4) role of transporters in yeast cell physiology, virulence and pathogenicity with a special focus on transporters involved in pH, membrane potential and cation homeostases, multidrug resistence and nutrient acquisition.

Selected Recent Publications

Arino J., Ramos J. & Sychrova H. (2010). Alkali-metal-cation transport and homeostasis in yeasts. Microbiol Mol Biol Rev. 75:  95-120

Kraidlova L., Van Zeebroeck G., Van Dijck P. & Sychrova H. (2011). The Candida albicans GAP gene family encodes permeases involved in general and specific amino acid uptake and sensing. Eukar Cell 10:1219-1229

Zahrádka J., Van Heusden G.P.H. & Sychrová H. (2012). Yeast 14-3-3 proteins participate in the regulation of cell cation homesotasis via interaction with Nha1 alkali-metal-cation/proton antiporter. BBA-General Subjects 1820: 843-858

Petrezsélyová S., Zimmermannová O. & Sychrová H. (2013).Vhc1, a novel transporter belonging to the family of electroneutral cation-Cl- cotransporters, participates in the regulation of cation content and morphology of S. cerevisiae vacuoles. BBA-Biomembranes 1828: 623-631