News

The Final ImResFun Scientific Conference of the EC-funded Marie-Curie Initial Training Network ImResFun is now announced.

Publication: Candidalysin is a fungal peptide toxin critical for mucosal infection

ITN Practical Course "C2a", Barcelona, Spain (May 10-15, 2015)

ITN Meeting, La Colle sur Loup, France (May 16, 2015)

HPF2015, La Colle sur Loup, France (May 16-22, 2015)

ITN Practical Course "S3" & "C3", Madrid, Spain (July 6-10, 2015)

ITN Mid-Term Review Meeting, Vienna, Austria (November 3, 2015)

ITN Practical Course "S5" & "C5", Tübingen, Germany (May 9-11, 2016)

ITN Lecture Course "S4" & "C4", Szeged, Hungary (July 2-8, 2016)

ITN Practical Course "S6" & "C6", Göttingen, Germany (October 26-28, 2016)

ITN Symposium "S7" & Final Consortium Meeting, Innsbruck, Austria (January 28-30, 2017)

 

Name & Address

Atilla Gacser Portrait

Attila GácserAssociate ProfessorImResFun Partner
University of Szeged, Department of Microbiology
Kozep fasor 52; H-6726 - Szeged, Hungary
Phone: +36-62-544-849 FAX: +36-62-544-823
e-mail:
Web: http://www2.sci.u-szeged.hu/microbiology/

ESR-MUW Project: (Start November/December 2013)

Infection models for analysis of C. parapsilosis host-pathogen interactions

The ESR will study the interplay between C. parapsilosis spp and human macrophages through qualitative/quantitative analyses of phagocytosis, fungicidal activity of immune cells, cytokine response and activation patterns. NGS RNA-Seq to examine host-fungi interactions.

Main Research Interests

Candida species are the most common cause of opportunistic fungal infections worldwide. Besides C. albicans, which is responsible for the majority of invasive candidiasis cases, the incidence of non-albicans species has largely increased over the past decades. Our group is particularly interested in the molecular mechanisms underlying C. parapsilosis infections. Although there has been a great progress in the understanding of the interactions between C. albicans and the host, little is known about the virulence properties of C. parapsilosis as well as about the immune response induced by this pathogen. However, it is well known that the two species differ from each other in some respects. For example, while C. albicans is able to cause disease with the same probability at any age, C. parapsilosis causes infections predominantly in newborns and children under the age of two. Together with other findings, exploration of the molecular mechanisms underlying these differences could contribute to the development of more effective antifungal therapies.

Our group focuses on the understanding of the virulence of Candida species, with special focus on C. parapsilosis. We aim to investigate the molecular mechanisms underlying Candida infections approaching from both the host and the pathogen perspective.

Specific research topics and aims of our group involve: (i) establishment of a C. parapsilosis mutant collection to explore the role of specific fungal genes in virulence, (ii) investigation of immunomodulatory function of hydrolytic enzymes (lipases, proteases) produced by C. parapsilosis, (iii) examination of the role of C. parapsilosis prostaglandin-like molecules during host-pathogen interactions, (iv) understanding of the role of TAM receptors in Candida infections, (v) investigation of the innate and adaptive immune responses induced by C. parapsilosis, (vi) understanding of the evolution of the C. parapsilosis sensu lato group.

Selected Recent Publications

Tóth A, Csonka K, Jacobs C, Vágvölgyi C, Nosanchuk JD, Netea MG, Gácser A. (2013) Candida albicans and Candida parapsilosis Induce Different T-Cell Responses in Human Peripheral Blood Mononuclear Cells. J Infect Dis. 2013 May 31

Németh T, Tóth A, Szenzenstein J, Horváth P, Nosanchuk JD, Gácser A (2013) Characterization of virulence properties in the C. parapsilosis sensu lato species PLOS ONE accepted

Horváth P, Nosanchuk JD, Hamari Z, Vágvölgyi C, Gácser A. (2012) The identification of gene duplication and the role of secreted aspartyl proteinase 1 in Candida parapsilosis virulence. J Infect Dis.;205(6):923-33. doi: 10.1093/infdis/jir873. Epub 2012 Feb 1.